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KMID : 0931320200200020153
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대한상부위장관.헬리코박터학회지
2020 Volume.20 No. 2 p.153 ~ p.158
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Changes in the Eradication Efficacy of Fluoroquinolone-containing Triple Therapy for Helicobacter pylori Infection in Korea
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Lee Jung-Won
Kim Na-Young
Kim Geun
Kim Si-Ho
Nam Hwa-Won
Lee Si-Won
Shin Cheol-Min
Park Young-Soo
Lee Dong-Ho
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Abstract
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Background/Aims: Fluoroquinolone-containing triple eradication therapy could be considered an alternative regimen for the second- line treatment of Helicobacter pylori infection. This study aimed to investigate the changes in the eradication efficacy of fluoroquinolone- containing triple therapy from 2003 to 2018 in Korea.Materials and
Methods: Patients with a history of first-line eradication therapy failure were consecutively enrolled at Seoul National University Bundang Hospital from 2003 to 2018. All patients took moxifloxacin-containing triple therapy as the second-line eradication therapy. The treatment regimen comprised a three-drug combination comprising a proton pump inhibitor, amoxicillin, and moxifloxacin. Data on age, sex, endoscopic diagnosis, eradication results, compliance, and adverse outcomes were acquired and analyzed.
Results: In total, 824 participants were enrolled during the study period, of whom, 46 were lost to follow-up. Finally, 778 participants were included in the per-protocol (PP) analysis, of whom, 72.1% received moxifloxacin-containing triple therapy for 14 days. The eradication rate of moxifloxacin-containing triple therapy was 72.1% (594/824) in the intention-to-treat analysis and 76.3% (594/778) in the PP analysis. A decline in eradication efficacy was observed, especially in the PP analysis (P=0.046). Diarrhea was the most commonly observed adverse event, accounting for 19.6% (41/209) of recorded adverse events.
Conclusions: Moxifloxacin-containing triple therapy has shown suboptimal eradication efficacy as the second-line eradication therapy. In addition, there is a concern that eradication rate will decrease due to increase in antimicrobial resistance.
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KEYWORD
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Eradication rate, Fluoroquinolones, Helicobacter pylori, Triple therapy
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